3H-Imidazo[4,5-b]pyridine-2-thiol

3H-Imidazo[4,5-b]pyridine-2-thiol - Names and Identifiers

Name	1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione
Synonyms	4-AZA-2-MERCAPTOBENZIMIDAZOLE 2-Thio-1H-imidazo[4,5-b]pyridine 1H-IMIDAZO[4,5-B]PYRIDINE-2-THIOL 1H-imidazo[4,5-b]pyridine-2-thiol 3H-imidazo[4,5-b]pyridine-2-thiol 3H-Imidazo[4,5-b]pyridine-2-thiol 1H-IMIDAZO[4,5-B]PYRIDINE-2(3H)-THIONE 1,3-dihydroimidazo[4,5-b]pyridine-2-thione 1,3-dihydro-2H-imidazo[4,5-b]pyridine-2-thione 1,3-Dihydro-2H-imidazo[4,5-b]pyridine-2-thione 2H-IMidazo[4,5-b]pyridine-2-thione, 1,3-dihydro- 2H-Imidazo[4,5-b]pyridine-2-thione, 1,3-dihydro-
CAS	29448-81-5
InChI	InChI=1/C6H5N3S/c10-6-8-4-2-1-3-7-5(4)9-6/h1-3H,(H2,7,8,9,10)

3H-Imidazo[4,5-b]pyridine-2-thiol - Physico-chemical Properties

Molecular Formula	C6H5N3S
Molar Mass	151.19
Density	1.59±0.1 g/cm3(Predicted)
Melting Point	>300 °C
Boling Point	281.9±23.0 °C(Predicted)
Flash Point	140.3°C
Vapor Presure	0.000686mmHg at 25°C
pKa	7.91±0.20(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.76

3H-Imidazo[4,5-b]pyridine-2-thiol - Risk and Safety

Hazard Symbols

Xi - Irritant

3H-Imidazo[4,5-b]pyridine-2-thiol - Introduction

1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione (1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione) is an organic compound with the chemical formula C8H7N3S.

Nature:
1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione is a white crystalline solid with a weak thiol taste. It has good solubility, can be dissolved in alcohol and dimethylformamide under anhydrous conditions, slightly soluble in methanol, almost insoluble in water. This compound is relatively unstable in air and undergoes oxidation reactions.

Use:
1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione is an important organic synthesis intermediate that can be used to synthesize biologically active chemicals. It has a wide range of applications in the field of medicine and pesticides, and can be used as a lead compound for antibacterial drugs, inhibitors and other drugs.

Method:
1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione can be prepared in a variety of ways. The following is a common synthesis method:
First, 5-aminopyrimidine was dissolved in ethyl acetate, and sodium hydroxide solution was added to react to generate 5-aminoimidazo [4,5-b] pyridine.
Next, 5-aminoimidazo [4,5-b]pyridine and thioacetate are reacted under base catalysis to generate 1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione.

Safety Information:
1,3-dihydro-2h-imidazo [4,5-b]pyridine-2-thione is a chemical, and appropriate safety measures need to be taken during operation. It may irritate the eyes, skin, and respiratory tract, and may be harmful to the environment. During use, please wear appropriate protective gloves, protective glasses and protective mask to avoid direct contact with skin and eyes.

Last Update：2024-04-09 21:01:54